Valve have been working with Linaro to develop FOSS drivers for the Adreno 750. This is necessary, given how heavily Valve leans on having integrations with Mesa whereas Qualcomm's drivers are designed for an Android environment.

I don't see why they wouldn't unlock the bootloader, it wouldn't be the first Qualcomm-based product to allow it and in press interviews they have pressed, quite hard, that the Frame is still a PC.